My ASP.NET project failed to start this morning - VS.NET reported that "the web server is not running .NET 1.1" and my web project in the solution was unavailable....hhhmmm. IIS Manager reported the default website was not running and any attempt to start it resulted in an 0x8ffe2740 error code (and no decent message as usual!).
Bit of googling later it turns out that Skype's nicked port 80 off of IIS! Quite how it got it's paws on it I don't know as I haven't changed a single thing with IIS or Skype. TCPView confirmed Skype had port 80 and this blog post pointed me in the direction of the option disabling Skype from using port 80 so all is well again.
It would have to happen on a Monday....I hate Mondays!